Still a puzzle: why is haem covalently attached in c-type cytochromes?

Structure. 1999 Dec 15;7(12):R281-90. doi: 10.1016/s0969-2126(00)88334-3.


c-Type cytochromes are a group of proteins with diverse structures and functions. Their common feature is covalent attachment of haem to one or more CXXCH motifs. There does not seem to be a single advantageous reason for this covalent attachment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Cytochrome c Group / chemistry*
  • Heme / chemistry*
  • Models, Molecular
  • Protein Conformation
  • Protein Structure, Secondary


  • Cytochrome c Group
  • Heme