A randomized controlled trial of intracameral lidocaine during phacoemulsification under topical anesthesia

Ophthalmology. 2000 Jan;107(1):68-71. doi: 10.1016/s0161-6420(99)00016-0.

Abstract

Objective: To test the hypothesis that adjunctive intracameral 1% lidocaine reduces intraoperative pain during phacoemulsification using topical anesthesia.

Design: Prospective, double-masked, randomized, controlled trial.

Participants: A total of 200 patients undergoing routine phacoemulsification under topical 1% tetracaine were studied.

Intervention: Randomization to 0.5 ml intracameral, unpreserved, epinephrine-free 1% lidocaine or placebo was conducted.

Main outcome measure: Intraoperative pain was quantified by the patients using a 0-10 visual analog pain scale.

Results: Intraoperative pain scores (+/- standard deviation) for the lidocaine and control groups were 1.29 +/-1.24 and 1.44 +/- 1.33, respectively (P > 0.35).

Conclusions: In a rigorously double-masked, prospective, randomized, controlled trial there was no significant reduction in intraoperative pain when intracameral 1% lidocaine was used during phacoemulsification under topical anesthesia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anesthesia, Local / methods*
  • Anesthetics, Local / therapeutic use*
  • Anterior Chamber / drug effects*
  • Capsulorhexis
  • Double-Blind Method
  • Female
  • Humans
  • Intraoperative Complications / prevention & control
  • Lens Implantation, Intraocular
  • Lidocaine / therapeutic use*
  • Male
  • Middle Aged
  • Pain / etiology
  • Pain / prevention & control
  • Pain Measurement
  • Phacoemulsification* / adverse effects
  • Prospective Studies

Substances

  • Anesthetics, Local
  • Lidocaine