Correlation between human papillomavirus-associated cervical cancer and p53 codon 72 arginine/proline polymorphism

Hum Genet. 1999 Dec;105(6):564-6. doi: 10.1007/s004399900138.


High-risk mucosal human papillomaviruses encode an E6 oncoprotein, which binds the cellular p53 tumor suppressor protein, thereby marking it for degradation through the ubiquitin-mediated pathway. A common p53 polymorphism at codon-72 of exon 4 results in translation to either arginine or proline. Recently reported data suggested an increased susceptibility to E6/ubiquitin-mediated degradation of the Arg72-p53 isoform and an over-representation of the homozygous Arg72-p53 genotype in cervical cancer patients. We have analyzed this polymorphism in a larger series of patients with cervical cancer and in controls in the Czech Republic. We found no statistically significant differences between the codon-72 p53 genotypes of cervical cancer patients and the control women. Based on these results, it is unlikely that Arg72-p53 is associated with an increased risk for human papillomavirus-associated cervical tumor development in Czech women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amino Acid Substitution
  • Arginine / genetics*
  • Blood Donors
  • Codon
  • Czech Republic
  • DNA Mutational Analysis
  • Female
  • Genotype
  • Humans
  • Middle Aged
  • Papillomaviridae*
  • Papillomavirus Infections / complications*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Proline / genetics*
  • Tumor Suppressor Protein p53 / genetics*
  • Tumor Virus Infections / complications*
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / virology


  • Codon
  • Tumor Suppressor Protein p53
  • Arginine
  • Proline