Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli

J Leukoc Biol. 2000 Jan;67(1):97-103.


CD163, also referred to as M130, a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In freshly isolated monocytes the CD14bright CD16+ monocyte subset revealed the highest expression of CD163 among all monocyte subsets. CD163 mRNA and protein expression is up-regulated during macrophage colony-stimulating factor (M-CSF)-dependent phagocytic differentiation of human blood monocytes. In contrast, monocytic cells treated with GM-CSF and interleukin-4 (IL-4) for dendritic differentiation down-regulate this antigen. CD163 expression is also suppressed by proinflammatory mediators like lipopolysaccharide (LPS), interferon-gamma (IFN-gamma), and tumor necrosis factor alpha, whereas IL-6 and the antiinflammatory cytokine interleukin-10 (IL-10) strongly up-regulate CD163 mRNA in monocytes and macrophages. The effects of the immunosuppressants dexamethasone, cyclosporin A (CA), and cortisol differ in their capacity to influence CD163 mRNA levels. Our results demonstrate that CD163 expression in monocytes/macrophages is regulated by proinflammatory and antiinflammatory mediators. This expression pattern implies a functional role of CD 163 in the antiinflammatory response of monocytes.

MeSH terms

  • Antigens, CD*
  • Antigens, Differentiation, Myelomonocytic / metabolism*
  • Cells, Cultured
  • Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
  • Humans
  • Inflammation / metabolism*
  • Inflammation / pathology
  • Interferon-gamma / pharmacology
  • Interleukins / pharmacology
  • Lipopolysaccharides / pharmacology
  • Macrophage Colony-Stimulating Factor / pharmacology
  • Macrophages / metabolism*
  • Macrophages / pathology
  • Membrane Proteins*
  • Monocytes / metabolism*
  • Monocytes / pathology
  • Phagocytosis
  • Receptors, Cell Surface*
  • Receptors, Immunologic / metabolism
  • Receptors, Lipoprotein*
  • Receptors, Scavenger
  • Scavenger Receptors, Class B
  • Tumor Necrosis Factor-alpha / pharmacology


  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • CD163 antigen
  • Interleukins
  • Lipopolysaccharides
  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, Immunologic
  • Receptors, Lipoprotein
  • Receptors, Scavenger
  • Scarb1 protein, mouse
  • Scavenger Receptors, Class B
  • Tumor Necrosis Factor-alpha
  • Macrophage Colony-Stimulating Factor
  • Interferon-gamma
  • Granulocyte-Macrophage Colony-Stimulating Factor