Abstract
The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Brain
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Guinea Pigs
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Ileum / drug effects
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In Vitro Techniques
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Morphine Derivatives / pharmacology
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Nerve Tissue Proteins / pharmacology
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Oligopeptides / pharmacology*
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Receptors, Drug*
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Structure-Activity Relationship
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beta-Lipotropin / pharmacology*
Substances
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Morphine Derivatives
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Nerve Tissue Proteins
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Oligopeptides
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Receptors, Drug
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beta-Lipotropin