Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin

Proc Natl Acad Sci U S A. 1976 Jun;73(6):1821-3. doi: 10.1073/pnas.73.6.1821.

Abstract

The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain
  • Guinea Pigs
  • Ileum / drug effects
  • In Vitro Techniques
  • Morphine Derivatives / pharmacology
  • Nerve Tissue Proteins / pharmacology
  • Oligopeptides / pharmacology*
  • Receptors, Drug*
  • Structure-Activity Relationship
  • beta-Lipotropin / pharmacology*

Substances

  • Morphine Derivatives
  • Nerve Tissue Proteins
  • Oligopeptides
  • Receptors, Drug
  • beta-Lipotropin