MAP1B expression and microtubule stability in growing and regenerating axons

Microsc Res Tech. 2000 Jan 15;48(2):63-74. doi: 10.1002/(SICI)1097-0029(20000115)48:2<63::AID-JEMT2>3.0.CO;2-1.

Abstract

MAP1B is a microtubule-associated phosphoprotein that is particularly highly expressed in developing neurons. There is experimental evidence that it plays an important role in neuronal differentiation, especially the extension of axons and dendrites, but exactly what role is unclear. Recent experiments have shed light on the gene structure of MAP1B and identified some of the kinases that phosphorylate the protein. Implicit in these findings is the idea that MAP1B regulates the organisation of microtubules in neurites and is itself regulated in a complex way and at a number of levels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / enzymology
  • Axons / physiology*
  • Cell Differentiation
  • Enzyme Activation
  • Gene Expression Regulation, Developmental
  • Humans
  • Microtubule-Associated Proteins / genetics*
  • Microtubule-Associated Proteins / metabolism
  • Microtubule-Associated Proteins / physiology*
  • Microtubules / metabolism*
  • Nerve Regeneration*
  • Phosphoprotein Phosphatases / metabolism
  • Phosphorylation
  • Protein Binding
  • Protein-Serine-Threonine Kinases / metabolism

Substances

  • Microtubule-Associated Proteins
  • microtubule-associated protein 1B
  • Protein-Serine-Threonine Kinases
  • Phosphoprotein Phosphatases