Histone acetyltransferase complexes and their link to transcription

Crit Rev Eukaryot Gene Expr. 1999;9(3-4):231-43. doi: 10.1615/critreveukargeneexpr.v9.i3-4.80.


Early studies revealing the relationship between the state of histone acetylation and gene transcription were largely indirect. Increasing information regarding the enzymes that catalyze transcription linked acetylation is beginning to clarify this issue. This review attempts to relate previous data regarding the distribution of histone acetylation within different chromatin regions with recent data regarding the substrate specificity, subunit composition, and recruitment of the known histone acetyltransferase complexes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetyltransferases / genetics*
  • Acetyltransferases / metabolism
  • Animals
  • Cell Nucleus / enzymology
  • Cell Nucleus / genetics*
  • Histone Acetyltransferases
  • Histones / genetics*
  • Histones / metabolism
  • Humans
  • Saccharomyces cerevisiae Proteins*
  • Transcription, Genetic*


  • Histones
  • Saccharomyces cerevisiae Proteins
  • Acetyltransferases
  • Histone Acetyltransferases