The Tat Protein Export Pathway

Mol Microbiol. 2000 Jan;35(2):260-74. doi: 10.1046/j.1365-2958.2000.01719.x.

Abstract

The Tat (twin-arginine translocation) system is a bacterial protein export pathway with the remarkable ability to transport folded proteins across the cytoplasmic membrane. Preproteins are directed to the Tat pathway by signal peptides that bear a characteristic sequence motif, which includes consecutive arginine residues. Here, we review recent progress on the characterization of the Tat system and critically discuss the structure and operation of this major new bacterial protein export pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism*
  • Biological Transport
  • Cell Membrane / metabolism
  • Gram-Negative Bacteria / genetics
  • Gram-Negative Bacteria / metabolism*
  • Molecular Sequence Data
  • Protein Folding
  • Protein Sorting Signals / chemistry
  • Protein Sorting Signals / genetics
  • Protein Sorting Signals / metabolism*

Substances

  • Bacterial Proteins
  • Protein Sorting Signals