Abstract
The immune response to infection can vary markedly in different organs of the same animal. In some organs, the infection can resolve with subsequent immunity to re-infection, whereas in other organs, pathogens can persist. Here, Christian Engwerda and Paul Kaye highlight the importance of defining organ-specific immune mechanisms for developing strategies that deal effectively with infectious diseases and their associated pathologies.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Disease Progression
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Inflammation
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Killer Cells, Natural / physiology
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Leishmania donovani / pathogenicity
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Leishmania infantum / pathogenicity
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Leishmaniasis, Visceral / immunology*
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Leishmaniasis, Visceral / parasitology
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Leishmaniasis, Visceral / physiopathology
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Mice
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Organ Specificity / immunology*
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Spleen / immunology
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Spleen / parasitology
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T-Lymphocytes / physiology
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Viscera / immunology*
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Viscera / parasitology*
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Viscera / pathology