Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases

Immunol Today. 2000 Feb;21(2):78-82. doi: 10.1016/s0167-5699(99)01552-2.


Oxidative stress at sites of chronic inflammation can cause permanent genetic changes. The development of mutations in the p53 tumor suppressor gene and other key regulatory genes could help convert inflammation into chronic disease in rheumatoid arthritis and other inflammatory disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Arthritis, Rheumatoid / genetics
  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / metabolism*
  • Bursa, Synovial / cytology
  • Bursa, Synovial / metabolism
  • Genes, p53 / drug effects
  • Genes, p53 / genetics
  • Humans
  • Mutation
  • Oxidative Stress / physiology*
  • Reactive Oxygen Species / metabolism
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*


  • Reactive Oxygen Species
  • Tumor Suppressor Protein p53