The beta cell in autoimmune diabetes: many mechanisms and pathways of loss

Trends Endocrinol Metab. Jan-Feb 2000;11(1):11-5. doi: 10.1016/s1043-2760(99)00210-6.


Death of pancreatic beta cells is the final step in the pathogenesis of type 1 diabetes before it becomes clinically apparent. Applying recent basic research about how cells die to the clinical problem of diabetes is a current opportunity and challenge. To date, perforin is the only factor definitely implicated in beta-cell killing in the non-obese diabetic (NOD) mouse model, although some perforin-deficient NOD mice develop diabetes. Our results suggest that other factors that cause beta-cell death remain to be identified.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology*
  • Diabetes Mellitus / immunology
  • Diabetes Mellitus / pathology*
  • Humans
  • Islets of Langerhans / immunology
  • Islets of Langerhans / pathology*
  • Signal Transduction / physiology*