Ceramide in the eukaryotic stress response

Trends Cell Biol. 2000 Feb;10(2):73-80. doi: 10.1016/s0962-8924(99)01694-3.


Several extracellular agents and stress stimuli, such as tumour necrosis factor alpha, chemotherapeutic agents and heat, cause ceramide accumulation. They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Ceramides / metabolism*
  • Ceramides / pharmacology
  • Ceramides / physiology*
  • Humans
  • Signal Transduction / drug effects
  • Sphingomyelins / metabolism
  • Sphingomyelins / physiology
  • Stress, Physiological / metabolism*


  • Ceramides
  • Sphingomyelins