Functions of LIM-homeobox genes

Trends Genet. 2000 Feb;16(2):75-83. doi: 10.1016/s0168-9525(99)01883-1.


Homeobox genes play fundamental roles in development. They can be subdivided into several subfamilies, one of which is the LIM-homeobox subfamily. The primary structure of LIM-homeobox genes has been remarkably conserved through evolution. Have their functions similarly been conserved? A host of new data has been derived from mutational analysis in diverse organisms, such as nematodes, flies and vertebrates. These studies have revealed a prominent involvement of LIM-homeodomain proteins in tissue patterning and differentiation, and their function in neural patterning is evident in all organisms studied to date. Here, we summarize the recent findings on LIM-homeobox gene function, compare the function of these genes from different organisms and describe specific co-factor requirements.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics
  • Drosophila / genetics
  • Evolution, Molecular
  • Genes, Homeobox / genetics*
  • Genes, Homeobox / physiology*
  • Humans
  • Models, Genetic
  • Multigene Family
  • Mutation
  • Phylogeny
  • Protein Binding
  • Transcription, Genetic