Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons

Trends Neurosci. 2000 Feb;23(2):80-8. doi: 10.1016/s0166-2236(99)01492-7.


Metabotropic glutamate receptors (mGluRs) can increase intracellular Ca2+ concentration via Ins(1,4,5)P3- and ryanodine-sensitive Ca2+ stores in neurons. Both types of store are coupled functionally to Ca2+-permeable channels found in the plasma membrane. The mGluR-mediated increase in intracellular Ca2+ concentration can activate Ca2+-sensitive K+ channels and Ca2+-dependent nonselective cationic channels. These mGluR-mediated effects often result from mobilization of Ca2+ from ryanodine-sensitive, rather than Ins(1,4, 5)P3-sensitive, Ca2+ stores, suggesting that close functional interactions exist between mGluRs, intracellular Ca2+ stores and Ca2+-sensitive ion channels in the membrane.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / metabolism
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Homer Scaffolding Proteins
  • Humans
  • Ion Channels / metabolism*
  • Neuronal Plasticity
  • Neurons / metabolism*
  • Neuropeptides / chemistry
  • Neuropeptides / genetics
  • Neuropeptides / metabolism
  • Potassium Channels / metabolism
  • Receptors, Metabotropic Glutamate / metabolism*
  • Ryanodine Receptor Calcium Release Channel / metabolism


  • Calcium Channels
  • Carrier Proteins
  • Homer Scaffolding Proteins
  • Ion Channels
  • Neuropeptides
  • Potassium Channels
  • Receptors, Metabotropic Glutamate
  • Ryanodine Receptor Calcium Release Channel
  • Calcium