Mammalian chromodomain proteins: their role in genome organisation and expression

Bioessays. 2000 Feb;22(2):124-37. doi: 10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E.

Abstract

The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromatin / chemistry
  • Chromatin / genetics*
  • Chromosomal Proteins, Non-Histone / chemistry
  • Chromosomal Proteins, Non-Histone / genetics
  • Gene Expression
  • Genome
  • Humans
  • Mice
  • Models, Molecular
  • Molecular Sequence Data
  • Polycomb-Group Proteins
  • Protein Conformation
  • Repressor Proteins / chemistry
  • Repressor Proteins / genetics
  • Sequence Homology, Amino Acid

Substances

  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Polycomb-Group Proteins
  • Repressor Proteins
  • heterochromatin-specific nonhistone chromosomal protein HP-1