A bird's eye view of global methylation

Nat Genet. 2000 Feb;24(2):101-2. doi: 10.1038/72730.


Restriction landmark genomic scanning applied to a broad variety of cancer types can disclose tumour-specific and tumour-type-specific global methylation profiles. This and other genome-scanning approaches allows the rapid analysis of methylation profiles of thousands of genes in parallel-and promises to identify new genes critical to carcinogenesis and other biological processes.

Publication types

  • Comment
  • News

MeSH terms

  • DNA Methylation*
  • Genes, Tumor Suppressor*
  • Germ-Line Mutation
  • Humans
  • Mutation*
  • Neoplasms / genetics*
  • Restriction Mapping