Effect of mebendazole on human cystic echinococcosis: the role of dosage and treatment duration

Ann Trop Med Parasitol. 1999 Jun;93(4):357-65. doi: 10.1080/00034989958357.


Fifty-three patients with single, multiple and/or multi-organ hydatid cysts were treated with mebendazole, in varying dosages (30-70 mg/kg.day) and over varying periods (6-24 months). Treatment failure was recorded if the mebendazole had no apparent effect on cyst morphology (monitored by radiology, ultrasonography and computed tomography) or only a parasitostatic effect (characterized by mixed and transitory, hypo- and hyper-echoic changes in the lesions). Cure was indicated by a parasitocidal effect (characterized by a totally echogenic picture, increased density of the cyst contents, reduction in the size or complete disappearance of the cysts, complete detachment of the endocysts and/or calcification of the cyst wall). Treatment failure was seen in about 40% of the patients and cure in about 38%; the other 23% had an intermediate result considered as an improvement. Cure rates increased both with dosage and duration, daily dosages of 60-70, 50 and 30-40 mg/kg curing 48%, 33% and 25%, respectively. The pre-treatment condition of any cysts should be taken into consideration when determining dosage and treatment duration.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anthelmintics / administration & dosage
  • Anthelmintics / therapeutic use*
  • Child
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Echinococcosis / diagnostic imaging
  • Echinococcosis / drug therapy*
  • Female
  • Humans
  • Male
  • Mebendazole / administration & dosage
  • Mebendazole / therapeutic use*
  • Middle Aged
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Ultrasonography


  • Anthelmintics
  • Mebendazole