Mapping quantitative trait loci for bovine ovulation rate

Mamm Genome. 2000 Feb;11(2):136-9. doi: 10.1007/s003350010026.


An elite, three-generation family from the USDA Meat Animal Research Center twinning population was examined for evidence of ovulation rate quantitative trait loci (QTL). This work was both a continuation of previously reported results suggesting evidence for ovulation rate QTL on bovine Chromosome (Chr) 7 and an extension of a genome-wide search for QTL. Additional markers were typed on Chr 7 to facilitate interval mapping and testing of the hypothesis of one versus two QTL on that chromosome. In addition, 14 other informative markers were added to a selective genotyping genome screening of this family, and markers exhibiting nominal significance were used to identify chromosomal regions that were then subjected to more exhaustive analysis. For Chr 7, a total of 12 markers were typed over a region spanning the proximal two-thirds of the chromosome. Results from interval mapping analyses indicated evidence suggestive of the presence of QTL (nominal P<0.00077) within this region. Subsequent analysis with a model postulating two QTL provided evidence (P<0.05) for two rather than one QTL on this chromosome. Preliminary analysis with additional markers indicated nominal significance (P<0.05) for regions of Chrs 5, 10, and 19. Each of these regions was then typed with additional markers for the entire three-generation pedigree. Significant evidence (P<0.000026) of ovulation rate QTL was found for Chrs 5 and 19, while support on Chr 10 failed to exceed a suggestive linkage threshold (P>0.00077).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cattle / genetics*
  • Chromosome Mapping*
  • Data Interpretation, Statistical
  • Female
  • Haplotypes
  • Lod Score
  • Microsatellite Repeats
  • Ovulation / genetics*
  • Quantitative Trait, Heritable