The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling

Biochim Biophys Acta. 2000 Feb 14;1470(1):M21-35. doi: 10.1016/s0304-419x(99)00032-3.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Cell Cycle / drug effects
  • Enzyme Activation
  • Focal Adhesion Protein-Tyrosine Kinases
  • Genes, Tumor Suppressor*
  • Germ-Line Mutation
  • Neoplasms / genetics
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases / chemistry
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphoinositide-3 Kinase Inhibitors*
  • Phosphoric Monoester Hydrolases / genetics*
  • Phosphoric Monoester Hydrolases / metabolism
  • Phosphoric Monoester Hydrolases / pharmacology
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Proto-Oncogene Proteins c-akt
  • Proto-Oncogene Proteins*
  • Signal Transduction / drug effects
  • Structure-Activity Relationship
  • Tumor Suppressor Proteins*

Substances

  • Phosphoinositide-3 Kinase Inhibitors
  • Proto-Oncogene Proteins
  • Tumor Suppressor Proteins
  • Protein-Tyrosine Kinases
  • Focal Adhesion Protein-Tyrosine Kinases
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase