[Malignant lymphoma with c-myc gene rearrangement in a patient receiving long-term treatment for multiple myeloma]

Rinsho Ketsueki. 1999 Dec;40(12):1265-70.
[Article in Japanese]


We encountered a 65-year-old woman with diffuse large B-cell lymphoma showing t(8;14)(q24;q32) and c-myc gene rearrangement that developed following 12 years of melphalan-based chemotherapy for multiple myeloma. Short-term remission was obtained by CHOP chemotherapy. However, shortly thereafter the patient died of an aggressive progression of lymphoma. It was suspected that the lymphoma was a secondary malignancy related to the treatment with cytotoxic agents and radiation for prolonged multiple myeloma. The chromosomal abnormality t(8;14)(q24;q32) is rare in secondary malignancies. Overexpression of c-myc by gene rearrangement may be associated with clinical courses manifested by the rapid progression of lymphoma.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Antineoplastic Agents, Alkylating / adverse effects
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 8
  • Fatal Outcome
  • Female
  • Gene Rearrangement*
  • Genes, myc / genetics*
  • Humans
  • Lymphoma, B-Cell / chemically induced
  • Lymphoma, B-Cell / genetics*
  • Melphalan / adverse effects
  • Multiple Myeloma / drug therapy*
  • Neoplasms, Second Primary / chemically induced
  • Neoplasms, Second Primary / genetics*
  • Translocation, Genetic


  • Antineoplastic Agents, Alkylating
  • Melphalan