Functional neuroimaging correlates of functional amnesia

Memory. Sep-Nov 1999;7(5-6):561-83. doi: 10.1080/096582199387751.


Especially in the field of memory encoding and retrieval, the results of functional neuroimaging have provided new insights in anatomico-functional interactions. In particular this holds true for the role of the prefrontal cortex in mnestic information processing, for the contribution and participation of the two hemispheres in various processes of information transmission, and for views on disturbed information processing after organically obvious and so-called psychogenic forms of memory impairments. This report particularly stresses the insights obtained by functional neuroimaging for probably environmentally triggered deficiencies in memory processing and discusses possible subtle neuroanatomical correlates of functional amnesias. It is especially emphasised that stress conditions and depressive states may modify the release of steroids (glucocorticoids) and transmitter agonists at the brain level with the consequence of selective memory disturbances which may manifest as a "mnestic block syndrome".

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amnesia / metabolism
  • Amnesia / physiopathology*
  • Brain / metabolism
  • Brain / physiopathology*
  • Depression / physiopathology
  • Humans
  • Prefrontal Cortex / physiopathology
  • Stress, Psychological / complications*
  • Stress, Psychological / metabolism