This study is based on a subsample of 15- and 16-year-old school students from the UK, part of the European School Project on Alcohol and Other Drugs (ESPAD). Information was available on truancy rates, perceived school performance, family structure, lifestyle, and usage of alcohol, cigarettes and illicit drugs in 6409 teenagers. Living in a single-parent family, lack of constructive hobbies, presence of psychiatric symptoms, and an aggressive outgoing delinquent lifestyle bore the strongest associations to truancy and to perceived school performance. There were also strong relationships between both these last two variables and use of alcohol, cigarettes, and illicit drugs. However, the effects of alcohol, cigarettes, and illicit drugs were largely accounted for by other variables. Having at least one parent who both supported the respondent and who exercised some control was predictive of better perceived school performance.