Abstract
Serum diamine oxidase (DAO) activity is very low, but is considered to reflect quantitative changes in small intestinal mass. Therefore, we measured DAO activity during chemotherapy in patients with hematological malignancies in order to evaluate mucosal injury. DAO activity decreased from 1-3 weeks after chemotherapy but returned to initial levels after 4 weeks. As the dosage of anti-cancer drugs increased, DAO activity decreased more, but its activity was not related to other parameters. These findings suggest that serum DAO could be used as an indicator of mucosal injury during chemotherapy.
MeSH terms
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Adult
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Aged
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Amine Oxidase (Copper-Containing) / blood*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Blood Proteins / metabolism
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Bone Marrow Transplantation
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Cholinesterases / blood
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Dose-Response Relationship, Drug
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Female
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Hematologic Neoplasms / drug therapy*
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Hematologic Neoplasms / enzymology*
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Humans
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Intestinal Mucosa / drug effects
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Intestinal Mucosa / enzymology*
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Intestine, Small / drug effects
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Intestine, Small / enzymology
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Leukemia / drug therapy
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Leukemia / enzymology
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Leukocyte Count / drug effects
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Lymphoma, B-Cell / drug therapy
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Lymphoma, B-Cell / enzymology
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Male
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Middle Aged
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Serum Albumin / metabolism
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Time Factors
Substances
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Blood Proteins
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Serum Albumin
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Amine Oxidase (Copper-Containing)
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Cholinesterases