Leukocyte migration: scent of the T zone

Curr Biol. 2000 Jan 13;10(1):R30-3. doi: 10.1016/s0960-9822(99)00253-5.

Abstract

Recent studies show that the chemokine receptor CCR7 helps T lymphocytes and dendritic cells to navigate into the T-cell zone of lymphoid organs. Furthermore, down-modulation of CCR7 redirects some activated T cells from these zones into other lymphoid tissue compartments.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemokine CCL19
  • Chemokine CCL21
  • Chemokines, CC / deficiency
  • Chemokines, CC / genetics
  • Chemokines, CC / physiology
  • Chemotaxis, Leukocyte
  • Dendritic Cells / cytology*
  • Humans
  • Immunologic Deficiency Syndromes / genetics
  • Immunologic Deficiency Syndromes / pathology
  • Immunologic Memory
  • Langerhans Cells / cytology
  • Lymphocyte Cooperation
  • Lymphoid Tissue / cytology
  • Mice
  • Mice, Knockout
  • Mice, Mutant Strains
  • Receptors, CCR7
  • Receptors, Chemokine / deficiency
  • Receptors, Chemokine / genetics
  • Receptors, Chemokine / physiology*
  • T-Lymphocytes / cytology*

Substances

  • CCL19 protein, human
  • CCL21 protein, human
  • CCR7 protein, human
  • Ccl19 protein, mouse
  • Ccl21c protein, mouse
  • Ccr7 protein, mouse
  • Chemokine CCL19
  • Chemokine CCL21
  • Chemokines, CC
  • Receptors, CCR7
  • Receptors, Chemokine