Regulation of protein phosphatase-1

Chem Biol. 2000 Jan;7(1):R13-23. doi: 10.1016/s1074-5521(00)00069-7.


Reversible protein phosphorylation is a major regulatory mechanism of intracellular signal transduction. Protein phosphatase 1 (PP1) is one of four major types of serine-threonine phosphatases mediating signaling pathways, but the means by which its activity is modulated has only recently begun to come into focus.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Gene Expression Regulation, Enzymologic / genetics*
  • Humans
  • Molecular Sequence Data
  • Phosphoprotein Phosphatases / biosynthesis*
  • Phosphoprotein Phosphatases / genetics*
  • Protein Phosphatase 1
  • Regulatory Sequences, Nucleic Acid / genetics


  • Phosphoprotein Phosphatases
  • Protein Phosphatase 1