Soybean curd refuse alleviates experimental tumorigenesis in rat colon

Biosci Biotechnol Biochem. 1999 Dec;63(12):2256-8. doi: 10.1271/bbb.63.2256.


Adult Fischer-344 rats which underwent administration of azoxymethane were fed diets containing soybean curd refuse (SCR) or a high-molecular-weight fraction of soy protein digest (HMF), or Hammarsten casein (CAS) as a protein source over a period of 34 weeks. All the living rats of each group at 22, 28 or 34 weeks were endoscopically inspected for tumor incidence in the colon. SCR turned out to be comparable to HMF in anti-tumorigenicity, or rather better than HMF.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Azoxymethane
  • Carcinogens
  • Colonic Neoplasms / chemically induced
  • Colonic Neoplasms / drug therapy*
  • Diet
  • Dietary Proteins / pharmacology
  • Male
  • Molecular Weight
  • Plant Extracts / therapeutic use*
  • Rats
  • Rats, Inbred F344
  • Soybeans*


  • Carcinogens
  • Dietary Proteins
  • Plant Extracts
  • Azoxymethane