Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease

Hum Pathol. 2000 Jan;31(1):126-8. doi: 10.1016/s0046-8177(00)80210-5.


Benign metastasizing leiomyoma (BML) is a rare condition, characterized by the occurrence of multiple smooth-muscle nodules, most often located in the lung after previous hysterectomy because of histologically benign appearing leiomyoma. Although the condition resembles a metastatic process, case studies provided evidence that it may be the result of an intravenous leiomyomatosis or an independent and multifocal smooth-muscle proliferation. Comparative genomic hybridization and X-chromosome inactivation analysis were used in a case of BML to determine whether pulmonary and uterine tumors are related one to another. A balanced karyotype, previously reported in leiomyomas and an identical X-chromosome inactivation pattern found in all tumorlets, is most consistent with a monoclonal origin of both uterine and pulmonary tumors and the interpretation that pulmonary lesions are metastatic.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Gene Silencing
  • Humans
  • Karyotyping
  • Leiomyoma / genetics
  • Leiomyoma / pathology*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Lung Neoplasms / secondary*
  • Nucleic Acid Hybridization
  • Tumor Cells, Cultured
  • Uterine Neoplasms / genetics
  • Uterine Neoplasms / pathology*
  • X Chromosome / genetics