Nodal signalling in vertebrate development

Nature. 2000 Jan 27;403(6768):385-9. doi: 10.1038/35000126.


Communication between cells during early embryogenesis establishes the basic organization of the vertebrate body plan. Recent work suggests that a signalling pathway centering on Nodal, a transforming growth factor beta-related signal, is responsible for many of the events that configure the vertebrate embryo. The activity of Nodal signals is regulated extracellularly by EGF-CFC cofactors and antagonists of the Lefty and Cerberus families of proteins, allowing precise control of mesoderm and endoderm formation, the positioning of the anterior-posterior axis, neural patterning and left-right axis specification.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Body Patterning / physiology
  • Embryonic Induction*
  • Forecasting
  • Mesoderm / physiology
  • Nodal Protein
  • Signal Transduction*
  • Transforming Growth Factor beta / physiology*


  • Nodal Protein
  • Transforming Growth Factor beta