Synthesis and antinociceptive activity of some 3-substituted benzothiazolone derivatives

Farmaco. 1999 Nov-Dec;54(11-12):846-51. doi: 10.1016/s0014-827x(99)00111-1.

Abstract

Thirteen 3-substituted benzothiazolone derivatives have been synthesized. Their chemical structures have been elucidated by IR and NMR spectral data and by elemental analyses. Among these compounds, 1-¿3-[2(3H)-benzothiazolon-3-yl[propanoyl]morpholine (5b); 1-¿3-[2(3H)-benzothiazolon-3-yl[propanoyl]-4-benzylpiperidine++ + (5c); 1-¿3-[2(3H)-benzothiazolon-3-yl[-propanoyl]-4-phenylpiperazine (5d); 3-[3-(4-benzylpiperidine-1-yl)propyl]-2(3H)-benzothiazolone (5k); 3-[3-(4-benzylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5I); 3-[3-(4-phenylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5m) have been found to be significantly more active than the others.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics, Non-Narcotic / chemical synthesis*
  • Analgesics, Non-Narcotic / pharmacology*
  • Animals
  • Female
  • Magnetic Resonance Spectroscopy
  • Male
  • Mice
  • Molecular Structure
  • Thiazoles / chemical synthesis*
  • Thiazoles / pharmacology*

Substances

  • Analgesics, Non-Narcotic
  • Thiazoles