Steroid/nuclear receptor coactivators

Vitam Horm. 2000;58:391-448. doi: 10.1016/s0083-6729(00)58032-7.

Abstract

In higher eukaryotes, steroids/thyroid hormones and many lipophilic compounds regulate cellular physiology through binding to the steroid/nuclear receptor proteins. Steroid/nuclear receptors are ligand-dependent transcriptional activators that can stimulate gene expression. This transcriptional activation plays a pivotal role in hormone-regulated physiological and pharmacological responses. In recent years, several steroid/nuclear receptor cofactors have been identified and found to interact with the receptor and modulate its transcriptional activity. Among these cofactors, a family of three co-activators has been the focus of intense studies. Although gaps remain, progress has been made in understanding how a given co-activator interacts with the receptor and promotes transcriptional activation. We are beginning to understand co-activator action; for instance, several studies have established the molecular basis of antagonism by anti-hormones and the connection of co-activators with human cancers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Crystallography, X-Ray
  • Histone Acetyltransferases
  • Humans
  • Molecular Sequence Data
  • Nuclear Receptor Coactivator 1
  • Receptors, Steroid* / metabolism
  • Transcription Factors* / chemistry
  • Transcription Factors* / pharmacology
  • Transcription Factors* / physiology
  • Transcriptional Activation

Substances

  • Receptors, Steroid
  • Transcription Factors
  • Histone Acetyltransferases
  • NCOA1 protein, human
  • Nuclear Receptor Coactivator 1