The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma

J Allergy Clin Immunol. 2000 Feb;105(2 Pt 2):S487-92. doi: 10.1016/s0091-6749(00)90048-4.


The beta(2)-adrenergic receptor (beta(2)AR) is the molecular target for beta-agonists used in the treatment of asthma. In the human population, 4 polymorphisms of the beta(2)AR coding block have been found, 3 of which result in receptors that have different properties compared with wild-type. To date, clinical studies suggest that these beta(2)AR polymorphisms may alter asthmatic phenotype and the response to beta-agonist therapy, making these variants the first of undoubtedly several genetic loci that will ultimately be found that will provide for individualized therapy in asthma.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adrenergic beta-Agonists / therapeutic use*
  • Amino Acid Sequence
  • Asthma / drug therapy*
  • Asthma / genetics*
  • Clinical Trials as Topic
  • Genetic Variation
  • Humans
  • Molecular Sequence Data
  • Receptors, Adrenergic, beta / genetics*


  • Adrenergic beta-Agonists
  • Receptors, Adrenergic, beta