Molecular mechanisms of IgE regulation

J Allergy Clin Immunol. 2000 Feb;105(2 Pt 2):S547-58. doi: 10.1016/s0091-6749(00)90059-9.


IgE antibody plays an important role in allergic diseases. IgE synthesis by B cells requires two signals. The first signal is delivered by the cytokines IL-4 or IL-13, which target the Cepsilon gene for switch recombination. The second signal is delivered by interaction of the B cell surface antigen CD40 with its ligand (CD40L) expressed on activated T cells. This activates deletional switch recombination. We review the molecular mechanisms of IL-4 and CD40 signaling that lead to IgE isotype switching and discuss the implications for intervening to abort or suppress the IgE antibody response.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / physiology*
  • CD40 Antigens / metabolism
  • CD40 Antigens / physiology
  • CD40 Ligand
  • Gene Rearrangement*
  • Humans
  • Immunoglobulin E / metabolism
  • Immunoglobulin E / physiology*
  • Interleukin-13 / physiology
  • Interleukin-4 / physiology
  • Membrane Glycoproteins / metabolism
  • Models, Biological
  • Signal Transduction
  • T-Lymphocytes / physiology


  • CD40 Antigens
  • Interleukin-13
  • Membrane Glycoproteins
  • CD40 Ligand
  • Interleukin-4
  • Immunoglobulin E