Interferon-gamma-independent CD8+ T cell-mediated protective anti-malaria immunity elicited by recombinant adenovirus

Parasite Immunol. 2000 Mar;22(3):157-60. doi: 10.1046/j.1365-3024.2000.00289.x.


Recombinant adenovirus, expressing the CS protein of Plasmodium yoelii, AdPyCS, was shown to induce a comparable degree of T cell-mediated protection against malaria as a single dose of irradiated P. yoelii sporozoites, causing inhibition of liver stage development. We now report that differently from sporozoite-induced immunity, interferon (IFN)-gamma does not mediate the protective immunity induced by AdPyCS, since a similar degree of protection was observed in AdPyCS immunized mice lacking IFN-gamma-/- and the IFN-gamma receptor (IFN-gammaR-/-) compared to that in wild-type mice. Depletion of CD8+ T cells from these immunized mice almost completely abolished the AdPyCS-induced immunity, indicating that the immunization with AdPyCS induces CD8+ T cell-mediated protective anti-malaria immunity, which is independent of IFN-gamma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoviridae / genetics*
  • Adenoviridae / immunology
  • Animals
  • CD8-Positive T-Lymphocytes / immunology*
  • Immunization
  • Interferon-gamma / immunology*
  • Liver / parasitology
  • Malaria / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Plasmodium yoelii / growth & development
  • Plasmodium yoelii / immunology
  • Protozoan Proteins / administration & dosage
  • Protozoan Proteins / genetics
  • Protozoan Proteins / immunology*
  • Recombinant Proteins / immunology


  • Protozoan Proteins
  • Recombinant Proteins
  • circumsporozoite protein, Protozoan
  • Interferon-gamma