Pre-natal ventriculomegaly and hydrocephalus

Neurol Res. 2000 Jan;22(1):37-42. doi: 10.1080/01616412.2000.11741036.


Ultrasonic imaging of the human fetal brain has allowed ventriculomegaly and hydrocephalus to be categorized. In this study 40 fetuses with ventriculomegaly and 21 with an Arnold-Chiari malformation and a myelomeningocele had ventriculomegaly that resolved, stabilised or progressed in utero. Within the progressive group were those with hydrocephalus, hydrocephalus being defined as expansion of the cerebral ventricular atria together with disproportionate increase in the head circumference. The prognosis for fetuses with resolving and stable ventriculomegaly was good, reflecting the fact that the ventricular dilatation in these cases was probably caused by delayed parenchymal and cerebrospinal fluid pathway development. Whereas the prognosis for progressive ventriculomegaly was generally poor, suggesting that the causes were likely to have been chromosomal, genetic, an infective agent or a catastrophic event which had an adverse effect on parenchymal development. The causes of hydrocephalus also adversely affected brain development but additional damage was caused by raised intracranial pressure.

MeSH terms

  • Arnold-Chiari Malformation / diagnostic imaging
  • Arnold-Chiari Malformation / embryology
  • Brain / embryology*
  • Cerebral Ventricles / abnormalities*
  • Cerebral Ventricles / diagnostic imaging
  • Cerebral Ventricles / embryology
  • Disease Progression
  • Echoencephalography
  • Gestational Age
  • Humans
  • Hydrocephalus / diagnostic imaging*
  • Hydrocephalus / embryology*
  • Meningomyelocele / diagnostic imaging
  • Meningomyelocele / embryology
  • Remission, Spontaneous
  • Ultrasonography, Prenatal