DNA uptake signal sequences in naturally transformable bacteria

Res Microbiol. 1999 Nov-Dec;150(9-10):603-16. doi: 10.1016/s0923-2508(99)00130-8.


The naturally transformable bacterium Haemophilus influenzae Rd contains 1471 copies of the DNA uptake signal sequence (USS) 5'-AAGTGCGGT in its genome. Neisseria meningitidis contains 1891 copies of the USS sequence 5'-GCCGTCTGAA. The USSs are often found in the base paired stem of transcription terminators.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Base Sequence
  • Chi-Square Distribution
  • Consensus Sequence
  • DNA, Bacterial / genetics*
  • DNA, Bacterial / metabolism*
  • Genome, Bacterial*
  • Gram-Negative Bacteria / genetics*
  • Molecular Sequence Data
  • Nucleotide Mapping / methods
  • Sequence Alignment
  • Transcription, Genetic
  • Transformation, Bacterial / genetics*


  • DNA, Bacterial