Phospholipase A(2) enzymes: structural diversity in lipid messenger metabolism

Structure. 2000 Feb 15;8(2):R15-22. doi: 10.1016/s0969-2126(00)00097-6.


The phospholipases A(2) (PLA(2)s) are a large family of enzymes with varied lipidic products which are involved in numerous signal transduction pathways. The structural and functional characterization of several PLA(2)s have revealed the various mechanisms used by these enzymes to ingeniously manipulate the phospholipidic metabolic machinery.

Publication types

  • Review

MeSH terms

  • Calcium / metabolism
  • Catalytic Domain
  • Cytosol / enzymology
  • Enzyme Activation
  • Lipid Metabolism*
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism
  • Phospholipases A / chemistry
  • Phospholipases A / metabolism*
  • Protein Conformation


  • Membrane Proteins
  • Phospholipases A
  • Calcium