Severe hypoglycaemia caused by raised insulin-like growth factor II in disseminated breast cancer

J Clin Pathol. 1999 Oct;52(10):780-1. doi: 10.1136/jcp.52.10.780.

Abstract

A 60 year old woman with disseminated ductal carcinoma of the breast developed non-islet cell tumour induced hypoglycaemia (NICTH). The concentrations of the two insulin-like growth factors, IGF-I and IGF-II, were < 2 nmol/l and 94.1 nmol/l, respectively. The IGF-II to IGF-I ratio was > 47 (normal < 10). Insulin (< 3 mu/l) and C peptide (< 100 pmol/l) were both undetectable.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Papillary / blood*
  • Adenocarcinoma, Papillary / pathology
  • Bone Neoplasms / blood
  • Bone Neoplasms / pathology
  • Bone Neoplasms / secondary
  • Breast Neoplasms / blood*
  • Breast Neoplasms / pathology
  • Female
  • Humans
  • Hypoglycemia / blood*
  • Hypoglycemia / pathology
  • Immunohistochemistry
  • Insulin-Like Growth Factor I / analysis
  • Insulin-Like Growth Factor II / analysis*
  • Middle Aged
  • Skin Neoplasms / blood
  • Skin Neoplasms / pathology
  • Skin Neoplasms / secondary

Substances

  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II