Cytochrome P450-mediated drug interactions

Child Adolesc Psychiatr Clin N Am. 2000 Jan;9(1):43-76.


In this article, the authors have provided child psychiatrists with cytochromal concepts, illustrations of common CYP-based drug interactions, and CYP tables. Clinicians can use these tables to anticipate drug interactions. If two medications are listed on the same CYP, a drug interaction may occur, and depending on whether they are substrates, inducers, or inhibitors, clearance of one or both drugs may be altered. Because new information about CYPs rapidly becomes available, however, CYP tables have a short shelf life. To further predict and reduce the consequences of CYP-based drug interactions, child psychiatrists can limit their own formularies and review PubMed, Ovid, or other literature tracking programs each time they use two or more drugs (including nonpsychiatric ones). The following Internet websites can provide current CYP data: CYP charts http// armac ology/clinlist.html http// CYP drug interaction program http// AIDS drug interactions http// http// htm l http// ++ ion s/index.html http// le x_d rug.html.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adolescent
  • Animals
  • Child
  • Cytochrome P-450 Enzyme Inhibitors
  • Cytochrome P-450 Enzyme System / genetics
  • Cytochrome P-450 Enzyme System / physiology*
  • Drug Interactions / genetics
  • Drug Interactions / physiology*
  • Humans
  • Polymorphism, Genetic / genetics
  • Psychotropic Drugs / adverse effects*
  • Psychotropic Drugs / pharmacokinetics
  • Psychotropic Drugs / therapeutic use


  • Cytochrome P-450 Enzyme Inhibitors
  • Psychotropic Drugs
  • Cytochrome P-450 Enzyme System