Trichodysplasia spinulosa--a newly described folliculocentric viral infection in an immunocompromised host

J Investig Dermatol Symp Proc. 1999 Dec;4(3):268-71. doi: 10.1038/sj.jidsp.5640227.


This is a case report of an immunocompromised individual who presented with progressive alopecia, friable follicular spinous processes, and erythematous, indurated papules. Examination of skin biopsies using light microscopy and immunohistochemistry revealed pathologic changes of the follicular inner root sheath epithelium with dystrophic trichohyaline granules. Electron microscopy of thin sections of tissue revealed intracellular viral particles with a size and appearance consistent with those in the Papovaviridae family. Electron microscopy of negatively stained extract from a homogenized lesion also demonstrated icosahedral viruses with papovavirus morphology. We believe this is a previously unreported folliculocentric viral infection in an immunosuppressed human host and have termed this entity "trichodysplasia spinulosa".

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Facial Dermatoses / etiology
  • Facial Dermatoses / pathology
  • Facial Dermatoses / physiopathology
  • Facial Dermatoses / virology
  • Hair Diseases / etiology
  • Hair Diseases / pathology
  • Hair Diseases / physiopathology
  • Hair Diseases / virology*
  • Hair Follicle / pathology
  • Hair Follicle / physiopathology
  • Hair Follicle / virology*
  • Humans
  • Immunocompromised Host*
  • Male
  • Papillomavirus Infections* / complications
  • Papillomavirus Infections* / pathology
  • Papillomavirus Infections* / physiopathology