Abstract
Young adult Long-Evans female rats were subjected to intracerebroventricular injections of 150 microg 5,7-dihydroxytryptamine (5,7-DHT), 2 microg 192 IgG-saporin, or a combination of both neurotoxins. All rats were tested for olfactory recognition (short-term memory) using a task based on spontaneous exploration of odor sources. Compared with animals undergoing sham operations, 5,7-DHT reduced the concentration of serotonin by 60-80% in the frontoparietal cortex, hippocampus, striatum and the olfactory bulbs. After 192 IgG-saporin treatment, acetylcholine concentrations were reduced by approximately 40% in all these structures, except the striatum. Neither lesion induced a significant deficit in olfactory recognition. These data suggest that combined lesions of cholinergic and serotonergic neurons in the rat brain do not alter olfactory perception or olfactory short-term memory.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5,7-Dihydroxytryptamine / pharmacology
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Acetylcholine / metabolism*
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Analysis of Variance
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Animals
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Antibodies, Monoclonal / pharmacology
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Appetitive Behavior / drug effects
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Cholinergic Agents / pharmacology
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Corpus Striatum / metabolism
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Female
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Frontal Lobe / metabolism
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Hippocampus / metabolism
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Immunotoxins / pharmacology
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Injections, Intraventricular
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Memory, Short-Term / drug effects
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Memory, Short-Term / physiology*
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N-Glycosyl Hydrolases
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Norepinephrine / metabolism
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Olfactory Bulb / metabolism
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Parietal Lobe / metabolism
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Rats
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Rats, Long-Evans
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Ribosome Inactivating Proteins, Type 1
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Saporins
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Serotonin / metabolism*
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Serotonin Agents / pharmacology
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Smell / physiology*
Substances
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192 IgG-saporin
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Antibodies, Monoclonal
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Cholinergic Agents
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Immunotoxins
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Ribosome Inactivating Proteins, Type 1
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Serotonin Agents
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5,7-Dihydroxytryptamine
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Serotonin
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N-Glycosyl Hydrolases
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Saporins
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Acetylcholine
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Norepinephrine