Review: tissue engineering for regeneration of articular cartilage

Biomaterials. 2000 Mar;21(5):431-40. doi: 10.1016/s0142-9612(99)00213-6.


Joint pain due to cartilage degeneration is a serious problem, affecting people of all ages. Although many techniques, often surgical, are currently employed to treat this affliction, none have had complete success. Recent advances in biology and materials science have pushed tissue engineering to the forefront of new cartilage repair techniques. This review seeks to condense information for the biomaterialist interested in developing materials for this application. Articular cartilage anatomy, types of injury, and current repair methods are explained. The need for biomaterials, current commonly used materials for tissue-engineered cartilage, and considerations in scale-up of cell-biomaterial constructs are summarized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biocompatible Materials
  • Cartilage, Articular / injuries
  • Cartilage, Articular / physiology*
  • Cartilage, Articular / surgery*
  • Cell Transplantation*
  • Extracellular Matrix / physiology
  • Extracellular Matrix Proteins / physiology
  • Humans
  • Regeneration*


  • Biocompatible Materials
  • Extracellular Matrix Proteins