Failure of elimination of paternal mitochondrial DNA in abnormal embryos

Lancet. 2000 Jan 15;355(9199):200. doi: 10.1016/s0140-6736(99)03842-8.


Paternal mitochondrial DNA is normally eliminated from mammalian embryos. We have shown the presence of paternal mtDNA at the blastocyst stage in some abnormal human embryos.

Publication types

  • Letter

MeSH terms

  • Blastocyst
  • DNA, Mitochondrial* / genetics
  • Embryo, Mammalian
  • Fathers
  • Female
  • Fertilization in Vitro
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Pregnancy
  • Sperm Injections, Intracytoplasmic


  • DNA, Mitochondrial