Serial positron emission tomography (PET) in gliomatosis cerebri treated with radiotherapy: a case report

J Neurol Sci. 2000 Feb 1;173(1):25-31. doi: 10.1016/s0022-510x(99)00296-8.


Results of serial positron emission tomography (PET) in a biopsy-proven case of gliomatosis cerebri (GC) are reported. Computed tomography (CT) with and without contrast failed to detect focal abnormalities, but magnetic resonance (MR) revealed iso-intensity or low-intensity lesions in T1-weighted images and high-intensity lesions in T2-weighted images. Lesions were seen in the left thalamus, right temporal lobe and claustrum, and pons. Radiotherapy remarkably improved clinical and imaging findings. Both before and shortly after radiotherapy, 11C-methionine PET images showed hypermetabolism while 15O-water PET images showed a marked increase in cerebral blood flow in GC lesions. However, 6 months later PET images had remarkably improved, appearing nearly normal.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / radiotherapy*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neoplasms, Neuroepithelial / diagnostic imaging*
  • Neoplasms, Neuroepithelial / pathology
  • Neoplasms, Neuroepithelial / radiotherapy*
  • Tomography, Emission-Computed