Protein-only inheritance in yeast: something to get [PSI+]-ched about

Trends Cell Biol. 2000 Mar;10(3):98-105. doi: 10.1016/s0962-8924(99)01711-0.


Recent work suggests that two unrelated phenotypes, [PSI+] and [URE3], in the yeast Saccharomyces cerevisiae are transmitted by non-covalent changes in the physical states of their protein determinants, Sup35p and Ure2p, rather than by changes in the genes that encode these proteins. The mechanism by which alternative protein states are self-propagating is the key to understanding how proteins function as elements of epigenetic inheritance. Here, we focus on recent molecular-genetic analysis of the inheritance of the [PSI+] factor of S. cerevisiae. Insights into this process might be extendable to a group of mammalian diseases (the amyloidoses), which are also believed to be a manifestation of self-perpetuating changes in protein conformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Extrachromosomal Inheritance / genetics*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Glutathione Peroxidase
  • HSP70 Heat-Shock Proteins / metabolism
  • Heat-Shock Proteins / metabolism
  • Peptide Termination Factors
  • Phenotype
  • Prions / genetics
  • Prions / metabolism
  • Protein Binding / genetics
  • Protein Biosynthesis
  • Repressor Proteins / metabolism*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins*


  • Fungal Proteins
  • HSP70 Heat-Shock Proteins
  • Heat-Shock Proteins
  • Peptide Termination Factors
  • Prions
  • Repressor Proteins
  • SUP35 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • HsP104 protein, S cerevisiae
  • Glutathione Peroxidase
  • URE2 protein, S cerevisiae