Acetylcholine-mediated modulation of striatal function

Trends Neurosci. 2000 Mar;23(3):120-6. doi: 10.1016/s0166-2236(99)01501-5.


Striatal spiny neurones serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. these projection neurones also represent the main synaptic target of cholinergic interneurones, whose physiological role in striatal activity still remains largely enigmatic. The striatal cholinergic system has been implicated in the pathophysiology of movement disorders such as Parkinson's disease, but the cellular mechanisms underlying cholinergic-neurone function are still unknown. On the basis of in vitro electrophysiological evidence, obtained from a rat corticostriatal-slice preparation, we propose that endogenous ACh exerts a complex modulation of striatal synaptic transmission, which produces both short-term and long-term effects. ACh-mediated mechanisms might be of crucial importance in processing the cortical inputs to the striatum.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylcholine / metabolism*
  • Acetylcholine / pharmacology
  • Animals
  • Cells, Cultured
  • Corpus Striatum / anatomy & histology
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism*
  • Excitatory Amino Acids / biosynthesis
  • Humans
  • Interneurons / cytology
  • Interneurons / metabolism
  • Long-Term Potentiation / drug effects
  • Long-Term Potentiation / physiology
  • N-Methylaspartate / metabolism
  • Nerve Net / metabolism
  • Rats
  • Receptors, Muscarinic / metabolism
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology
  • gamma-Aminobutyric Acid / biosynthesis


  • Excitatory Amino Acids
  • Receptors, Muscarinic
  • gamma-Aminobutyric Acid
  • N-Methylaspartate
  • Acetylcholine