Statistical analysis of multi-subject fMRI data: assessment of focal activations

J Magn Reson Imaging. 2000 Jan;11(1):61-4. doi: 10.1002/(sici)1522-2586(200001)11:1<61::aid-jmri9>3.0.co;2-c.

Abstract

A simple procedure for analyzing multi-subject functional magnetic resonance imaging (fMRI) data is proposed. In the first step, a voxel-wise t-test across standardized z-maps is performed to identify areas that are consistently activated across subjects. In the second step, for each area, individual mean z-scores are calculated and subsequently subjected to an analysis of variance. An example is provided.

MeSH terms

  • Analysis of Variance
  • Brain / physiology*
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Memory, Short-Term