Treatment of infant colic with amino acid-based infant formula: a preliminary study

Acta Paediatr. 2000 Jan;89(1):22-7. doi: 10.1080/080352500750029004.


Infant colic, a common disorder of infancy, is characterized by excessive crying and fussing. In this preliminary study we examined whether Neocate, an amino acid-based formula, would be accepted by formula-fed infants with colic, 3-7 wk of age, and whether Neocate would improve their symptoms. Six infants with colic were studied using Barr-type infant behavior diaries for 3-6 d on their current formula and then for 5-17 d on Neocate exclusively. All infants tolerated Neocate well and all improved, usually within 1-2 d. The total time spent crying and fussing was reduced by an average of 45%, representing a decrease of 1.0 to 5.2 h daily. After colic symptoms improved, infants were challenged with oral doses of 75 mg of bovine IgG at a 1 mg/ml concentration in order to assess its potential role in colic. Bovine IgG challenges resulted in increased crying and fussing behavior, suggesting that this protein may be etiologically important.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Amino Acids / administration & dosage*
  • Animals
  • Carbohydrates / administration & dosage*
  • Cattle
  • Colic / diet therapy*
  • Colic / etiology
  • Crying
  • Dietary Fats / administration & dosage*
  • Food, Formulated*
  • Humans
  • Immunoglobulin G / administration & dosage
  • Immunoglobulin G / immunology
  • Infant
  • Infant Behavior
  • Infant Food*
  • Infant, Newborn
  • Male
  • Milk Hypersensitivity / complications
  • Time Factors


  • Amino Acids
  • Carbohydrates
  • Dietary Fats
  • Immunoglobulin G
  • Neocate