Aerosolized antimicrobial therapy in acutely ill patients

Pharmacotherapy. 2000 Feb;20(2):166-81. doi: 10.1592/phco.


Recent data are sparking renewed interest in therapy with aerosolized antimicrobials in critically ill patients as well as other populations such as those with neutropenia, human immunodeficiency virus infection, and cystic fibrosis. Pneumonia is a common complication in these patients and is associated with substantial morbidity and increased mortality. Clinical trials evaluated aerosolized antimicrobials for the prevention and treatment of pneumonia in hospitalized patients. In addition, factors that affect the pulmonary deposition of aerosolized drugs in mechanically ventilated patients were identified.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Administration, Inhalation
  • Aerosols
  • Anti-Infective Agents / administration & dosage*
  • Anti-Infective Agents / adverse effects
  • Anti-Infective Agents / therapeutic use*
  • Humans
  • Respiratory Tract Infections / drug therapy*
  • Respiratory Tract Infections / microbiology


  • Aerosols
  • Anti-Infective Agents