Treatment of dementia-associated agitation with gabapentin

J Neuropsychiatry Clin Neurosci. Winter 2000;12(1):40-3. doi: 10.1176/jnp.12.1.40.

Abstract

The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Three of 4 patients were successfully titrated to a full dose of 2,400mg/day. These findings suggest a possible role for gabapentin in the behavioral management of patients with dementia.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / adverse effects
  • Acetates / therapeutic use*
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / drug therapy*
  • Amines*
  • Anticonvulsants / adverse effects
  • Anticonvulsants / therapeutic use*
  • Cyclohexanecarboxylic Acids*
  • Dementia, Multi-Infarct / diagnosis
  • Dementia, Multi-Infarct / drug therapy*
  • Female
  • Gabapentin
  • Humans
  • Male
  • Mental Status Schedule
  • Neurologic Examination / drug effects
  • Psychomotor Agitation / diagnosis
  • Psychomotor Agitation / drug therapy*
  • gamma-Aminobutyric Acid*

Substances

  • Acetates
  • Amines
  • Anticonvulsants
  • Cyclohexanecarboxylic Acids
  • gamma-Aminobutyric Acid
  • Gabapentin