Vomeroglandin/CRP-Ductin is strongly expressed in the glands associated with the mouse vomeronasal organ: identification and characterization of mouse vomeroglandin

Biochem Biophys Res Commun. 2000 Feb 16;268(2):275-81. doi: 10.1006/bbrc.2000.2104.

Abstract

Vomeroglandin, a subform of mouse CRP-ductin, is a protein strongly expressed in the glands of mouse vomeronasal system. Both the proteins contain several of scavenger receptor cysteine-rich and CUB domains and one ZP domain. This domain arrangement is similar to those of rat Ebnerin, human DMBT1, and rabbit hensin. In situ hybridization analysis shows strong expression of vomeroglandin mRNA in the glands of vomeronasal system. Immunological analyses detect both membrane-bound and secreted forms of vomeroglandin. The secreted protein seems to be localized in the lumen of the vomeronasal organ, playing a certain role in the pheromone perception.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • COS Cells
  • Calcium-Binding Proteins
  • Cloning, Molecular
  • Concanavalin A / metabolism
  • DNA-Binding Proteins
  • Digestive System / metabolism
  • Female
  • Gene Library
  • Glycosylation
  • Humans
  • Male
  • Membrane Proteins / metabolism
  • Mice
  • Molecular Sequence Data
  • Mucins / biosynthesis*
  • Mucins / genetics
  • Protein Structure, Tertiary
  • RNA, Messenger / metabolism
  • Rabbits
  • Rats
  • Transfection
  • Tumor Suppressor Proteins
  • Vomeronasal Organ / metabolism*

Substances

  • Calcium-Binding Proteins
  • DNA-Binding Proteins
  • Dmbt1 protein, mouse
  • Membrane Proteins
  • Mucins
  • RNA, Messenger
  • Tumor Suppressor Proteins
  • Concanavalin A